Multiple choice questions

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For some of these questions, you need data from the appendices of Inorganic Chemistry, third edition by C.E. Housecroft and A.G. Sharpe. On opening the book cover you will find a periodic table and a list of elements and atomic masses. Physical constants are listed on the back inside cover of the book.

Multiple choice questions by Catherine E. Housecroft.

This activity contains 20 questions.

Which of the following amino acids is achiral?

	arginine (Arg)
	glycine (Gly)
	histidine (His)
	cysteine (Cys)

In oxyhaemoglobin, the iron centre is best described by which of the following?

	high-spin Fe(III)
	high-spin Fe(II)
	low-spin Fe(III)
	low-spin Fe(II)

In oxyhaemoglobin, the coordinated dioxygen is best described by which of the following?

	molecular O₂ with linear Fe–O–O
	molecular O₂ with bent Fe–O–O
	[O₂]^–
	[O₂]^2–

Which statement best describes haemerythrin?

	A haem protein
	A metalloprotein containing two active sites: one, a haem Fe and one, a non-haem Fe
	A non-haem protein with one Fe centre at the active site
	A non-haem protein with two Fe centres at the active site

Which statement correctly describes the function of cytochromes P-450?

	Cytochromes P-450 act as monooxygenases and catalyse the insertion of O into a C–H bond
	Cytochromes P-450 couple to cytochrome c in the mitochondrial electron-transfer chain
	Cytochromes P-450 act as dioxygenases
	Cytochromes P-450 contain high-spin Fe(III); this directly binds O₂ and acts as an O₂carrier

Which statement is incorrect about Types 1, 2 and 3 centres in blue copper proteins?

	A Type 1 centre exhibits an intense LMCT band in the electronic spectrum
	A Type 2 centre does not give rise to an EPR signal
	A Type 3 centre contains two Cu centres which are antiferromagnetically coupled
	A plastocyanin contains a Type 1 Cu centre

Which statement about Fe–S proteins is incorrect?

	A rubredoxin contains an FeS₄ unit, each S coming from a Cys residue
	A [2Fe–2S] ferredoxin contains six S donors, two of which are S^2– ligands
	A [4Fe–4S] ferredoxin contains a cubane core
	In a [4Fe–4S] ferredoxin, four redox couples that make use of the four Fe centres are accessible in Nature

The terminal member of the mitochondrial electron-transfer chain is:

	cytochrome P-450
	cytochrome c oxidase
	cytochrome c
	cytochrome c₁

Which statement about the Fe-only hydrogenases from bacteria isolated from C. pasteurianum and D. desulficans is correct?

	Fe-only hydrogenase contains [4Fe–4S] units and a unit consisting of an Fe₄S₄-cluster connected by a Cys residue to an Fe₂S₂-group
	Fe-only hydrogenase contains four [4Fe–4S] units as the active sites
	The active site in an Fe-only hydrogenase is an Fe₂(Cys)₂(His)₂ unit
	The active site in an Fe-only hydrogenase consists of an Fe₄S₄-cluster connected to an Fe₂S₂(Cys)₄-group

Nitrogenase contains:

	an Fe-protein and an FeMo-protein that operate in conjunction with each other
	an FeMo-protein in which the active site consists of a single [3FeMo-4S] cluster
	an FeMo-protein in which the P-cluster is in an irreversibly reduced state
	an Fe-only containing protein in which the P-cluster is the active site

Cytochrome c oxidase contains all but one of the following. Which one is the odd one out?

	A Cu₂ centre, bridged by two Cys residues
	A haem unit with two axial His units
	A Cu centre coordinated by three Cys residues
	A haem unit with one axial His residue, sited near a Cu centre coordinated by three His residues

Cytochrome c:

	is a haem protein
	accepts an electron from cytochrome coxidase in the mitochondrial electron-transfer chain
	is a non-haem protein
	is irreversibly oxidized in the mitochondrial electron-transfer chain

Which of the following is not involved in electron transfer?

	Carbonic anhydrase
	cytochrome b
	rubredoxin
	Rieske protein

Each part of this answer lists properties of Zn²⁺, which may or may not be correct. Which list gives properties that are correct and relevant to Zn-containing enzymes?

	Zn²⁺is a hard metal centre; it acts as a Lewis acid; it tolerates different coordination geometries
	Zn²⁺is a hard metal centre; it acts as a Lewis acid; it favours 4-coordination
	Zn²⁺ is a d¹⁰ ion; it is a soft metal centre; it acts as a Lewis acid
	Zn²⁺ is a d¹⁰ ion; it is a soft metal centre; it tolerates different coordination geometries

Studies of Zn(II)-containing proteins often make use of Co(II)-for-Zn(II) substitution. Which statement is correct?

	Tetrahedral coordination is one of several environments observed for both Co²⁺ and Zn²⁺
	Tetrahedral Co²⁺ and Zn²⁺ are both diamagnetic
	The ionic radius of Co²⁺ is significantly smaller than that of Zn²⁺
	The visible spectra of complexes of Co²⁺ are similar to those of related complexes of Zn²⁺

Thioneins are rich in which of the following amino acid residues?

	cysteine
	histidine
	glycine
	threonine

Haemocyanins are O₂-carrying copper-containing proteins in:

	mammals
	molluscs
	bacteria
	fungi

In studies of blue copper proteins, EPR spectroscopy is useful because:

	Cu(I) has one unpaired electron
	Cu(II) is paramagnetic
	Cu(II) and Cu(I) are both paramagnetic
	Cu(II) and Cu(I) have one and two unpaired electrons, respectively

Which of the following equilibria has the largest value of K? (Hae = haemoglobin)

	Hae + O₂ = Hae(O₂)
	Hae(O₂) + O₂ = Hae(O₂)₂
	Hae(O₂)₂ + O₂ = Hae(O₂)₃
	Hae(O₂)₃ + O₂ = Hae(O₂)₄

In what form is iron stored in the body?

	As transferrin
	As ferritin
	As haemoglobin
	As a siderophore

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