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Chapter 6: The analysis of deoxyribunucleic acid (DNA): DNA profiling Guest chapter by Harry Mountain

Try the multiple choice questions below to test your knowledge of Chapter 6. Once you have completed the test, click on 'Submit Answers for Grading' to get your results.

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This activity contains 10 questions.

Which of the following statements about tandem repetitive DNA are correct?

Tandem means two repeats next to each other.STRs are the same as microsatellite DNA.VNTRs are not a type of minisatellite DNA.It is usually classified according to the number of repeats.

To answer this question correctly, you may have to choose more than one response.

For the SGM⁺ system, which of the following are correct?

All the loci have many alleles (are multi-allelic).It is based on multiplex PCR.All the loci are STRs.All the loci are on the different chromosomes.

To answer this question correctly, you may have to choose more than one response.

Most of the loci in the SGM⁺ system are present in regions of “junk” DNA or in the intron regions of genes – this results in:

the phenotype of the person not being influenced by the genotype.the alleles being selectively neutral.the genotype having no health implications for the carrier.the genotypes at these loci not indicating anything about the physical attributes of the person.

In the SGM⁺ system, regarding the Amelogenin locus, which are true?

The locus examined is an STR.Two peaks in the analysis indicate the sample probably originated from a female.The allele on the Y chromosome is shorter than that on the X chromosome.Two peaks in the analysis indicate that the sample probably originated from a male.

To answer this question correctly, you may have to choose more than one response.

Which of the following points are correct for LCN DNA analysis?

It decreases the amount of evidence needed to generate a profile.It is used to analyse mtDNA.It is not based on STR analysis.It increases the sensitivity of the DNA profiling.

Just considering one locus, evidence at a crime scene shows a genotype of 5, 9 at the FGA locus. The allele frequencies for 5 and 9 are 0.120 and 0.320 respectively. How frequent would the genotype 5, 9 be expected to be in the population?

0.07680.01440.03840.1024

To answer this question correctly, you may have to choose more than one response.

Using SGM⁺, a profile which is found in evidence and a suspect is calculated to have a frequency of 5 x 10^-9. Which of the following statements are correct?

The likelihood ratio is 5 x 10^-9.The match probability is 1 in 2 x 10⁸.It is 2 x 10⁸ times more likely that the evidence originated from the suspect than another individual.One person in two-hundred million is expected to show the profile.

To answer this question correctly, you may have to choose more than one response.

A child has the genotype 12, 15 at the THO1 STR locus, which of the following couples could be its parents?

Woman 3, 5; man 12, 10.Woman 12, 15; man 8, 14.Woman 12, 10; man 8, 15.Woman 12, 12; man 8, 15.

To answer this question correctly, you may have to choose more than one response.

Which of the following statements about mtDNA are true?

Genes on the mtDNA are present in multi-copies whereas genes in nuclear DNA are present twice.Individuals carry maternal and paternal mtDNAs.Analysis is carried out using the SGM⁺ system.Genetic differences between individuals are mainly point mutations.

To answer this question correctly, you may have to choose more than one response.

Comparing the HV1 and HV2 mtDNA sequences from a person to members of their family - which of the following statements are true?

The mother’s sequences would be identical.All siblings would show the same sequence.Sisters would show identical sequences but brothers’ sequences would be different.The sequences would be identical to the father’s.

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